Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4141 | 4141-30326 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, L33F, G73T | G16A, N37D, I62V, L63P, A71V, P79A, I93L |
| >4141-30326| codons 1-99 PQITLWQRPFVTIKIAGQLKEALLDTGADDTVFEEMDLPGRWKPKIVGGIGGFVKVRQYD QVPIEICGHKVITTVLVGATPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | A62AV, K219N | Y181C | V108VI | V35M, T39A, K43E, E44EA, K101Q, V118I, K122E, D123E, K173E, Q174R, I178L, T200A, Q207E, D218E, A272P, D324E, I326M, G335D, M357R, A371V, T386I, K390R |
| >4141-30326| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEAGKISKIGPENPYNTPV FVIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRERNPDLVI CQYVDDLYVGSDLEIGQHRAKIEELREHLWRWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELMAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRGA HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |