<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4140 4140-30424 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K70Q, V75M K103KN   T39A, E40F, K43E, W88WC, V90I, V118I, K122E, E203D, Q207E, H208Y, R211K, K223KQ, A272P, K277R, V317VA, I326V, G333E, Q334E, G359S, T386I, K390R  
>4140-30424| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSDQWRKLMDFRELNKRTQDFCEIQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIDELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGAYYDPSKDLVAEIQKQEEGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10FI, L33LI, N83D, L89V V11VL, I13V, K20R, A22V, E34A, E35D, M36I, N37D, I62V, L63P, A71I, I72L, Q92K, I93L T91TCS
>4140-30424| codons 1-99
PQITLWQRPILTVKIGGQLREVLLDTGADDTVIADIDLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKILGTVLVGPTPVDVIGRNVMSKLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006