Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4140 | 4140-30424 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10FI, L33LI, N83D, L89V | V11VL, I13V, K20R, A22V, E34A, E35D, M36I, N37D, I62V, L63P, A71I, I72L, Q92K, I93L | T91TCS |
| >4140-30424| codons 1-99 PQITLWQRPILTVKIGGQLREVLLDTGADDTVIADIDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKILGTVLVGPTPVDVIGRNVMSKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | K70Q | K103KN | T39A, E40F, K43E, W88WC, V90I, V118I, K122E, E203D, Q207E, H208Y, R211K, K223KQ, A272P, K277R, V317VA, I326V, G333E, Q334E, G359S, T386I, K390R |
| >4140-30424| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSDQWRKLMDFRELNKRTQDFCEIQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIDELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLVAEIQKQEEGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |