Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4139 | 4139-30428 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N, N348I | Y181C | E6EK, K20R, V35I, E40F, K43E, V118I, K122E, H208Y, R211K, L228H, V245T, K277R, E297K, S322T, I329V, Q334E, M357T, K390R |
| >4139-30428| codons 1-399 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPTKDLIAEVQKQGEGQWTYQIYQEPFKILKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | G73S | L10I, I15V, L19LI, E35D, M36L, N37D, L38W, I62V, L63P, H69K, A71V |
| >4139-30428| codons 1-99 PQITLWQRPIVTIKVGGQIKEALLDTGADDTVLEDLDWPGRWKPKIIGGIGGFVKVRQYD QVPIEICGKKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |