<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4138 4138-30319 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M L10FI, G73ST T4TA, T12TK, I15V, L19P, K20I, E35D, M36I, I62IV, L63P, A71V, I72FL, I85V  
>4138-30319| codons 1-99
PQIALWQRPIVKIKVGGQPIEALLDTGADDTVLEDINLPGRWKPKIVGGIGGFVKVRQYD
QVPIEICGHKVLTTVLVGPTPVNVVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N K103N   K20R, V35M, K43N, E44D, V118I, K122E, D177DN, T200A, E203K, H208Y, R211K, K223E, L228H, A272P, K277R, A288T, I293V, S322T, Q334V, K350R, G359S, K366R, A371V, T377L, T386TI, K390R  
>4138-30319| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI
YQYVDDLYVGSDLEIGQHRAKIKELRQYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKTLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGVGQWTYQIYQEPFKNLRTGKYARMRSA
HTNDVRQLTEVVQKIALESIVIWGKIPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006