<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4137 4137-30320 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67HN, L74I, M184V, L210W, T215Y K219N K101P, Y188L   K43E, E44A, V60I, T69N, V118I, K122E, I142V, K166R, K173E, G196E, I202V, R211K, V245A, A272P, K277R, I293V, E297A, M357MT, R358K, T369A  
>4137-30320| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSNKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFREQNPDIVI
YQYVDDLLVGSDLEIEQHRTKVEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIALPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVKQLAEAVQKIATESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L33F, G73T, L89V I13V, E34Q, E35D, M36ML, N37S, G51A, D60E, I62V, L63P, I66F, A71V, I93L  
>4137-30320| codons 1-99
PQITLWQRPFVTVKIGGQLKEALLDTGADDTVFQDLSLPGRWKPKIIGGIAGFVKVRQYE
QVPIEFCGHKVITTVLVGPTPVNVIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006