Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4137 | 4137-30320 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, G73T, L89V | I13V, E34Q, E35D, M36ML, N37S, G51A, D60E, I62V, L63P, I66F, A71V, I93L |
| >4137-30320| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADDTVFQDLSLPGRWKPKIIGGIAGFVKVRQYE QVPIEFCGHKVITTVLVGPTPVNVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67HN, L74I, M184V, L210W, T215Y | K219N | K101P, Y188L | K43E, E44A, V60I, T69N, V118I, K122E, I142V, K166R, K173E, G196E, I202V, R211K, V245A, A272P, K277R, I293V, E297A, M357MT, R358K, T369A |
| >4137-30320| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI FAIKKKNSNKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFREQNPDIVI YQYVDDLLVGSDLEIEQHRTKVEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIALPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLAEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |