Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2090 | CA7724 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | ABC+ADV+IDV+NVP | 73 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, D67N, T69D, K70R | A62V, V75I, T215V, K219Q | K103T, V106A, Y181YC | V35L, C38CS, V90I, K122E, I135T, G196E, Q207E, F214L, E224D, L228R, A288T, E297K |
| >CA7724| codons 32-303 KALLEICTEMEKEGKISKIGPENPYNTPVFVIKRKNSDRWRKLIDFRELNKRTQDFWEIQ LGIPHPAGLKKTKSATVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQ GWKGSPAIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIEQHRTKIEELREHLLR WGLVTPDQKHQKDPPFRWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIY AGIKVKQLCKLLRGTKTLTEVIPLTKEAELEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, K20R, M36I, N37D, I62V, L63P, E65EG, A71V, T74S, I85V, I93L |
| >CA7725| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFVKVRQYD QVPIGICGHKVIGSVLVGPTPANIVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |