<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4136 4136-30321 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y N348I G190A   K20R, K43Q, A98S, V106I, V118I, D123E, T200AE, E203D, R211NS, A272P, K277R, K281R, T286P, I293V, E297K, K311R, D324E, K347KR, A376V, S379C, T386A  
>4136-30321| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSITVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVASDLEIGQHREKIDELRQHLWSWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGPKALTEVVPLTKEAE
LELAENREILREPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFRILKTGKYARMRGA
HTNDVKQLTEAVQKIVTECIVIWGKAPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, L90M   L10V, I13V, I15IV, K20T, D60E, L63P, I64V, I72IM, V77I, I93L  
>4136-30321| codons 1-99
PQITLWQRPVVTVKVGGQLTEALLDTGADDTILEEMNLPGRWKPKIVGGIGGFIKVRQYE
QIPVEICGHKAMGTVLIGPTPVNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006