Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4136 | 4136-30321 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | L10V, I13V, I15IV, K20T, D60E, L63P, I64V, I72IM, V77I, I93L |
| >4136-30321| codons 1-99 PQITLWQRPVVTVKVGGQLTEALLDTGADDTILEEMNLPGRWKPKIVGGIGGFIKVRQYE QIPVEICGHKAMGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | N348I | G190A | K20R, K43Q, A98S, V106I, V118I, D123E, T200AE, E203D, R211NS, A272P, K277R, K281R, T286P, I293V, E297K, K311R, D324E, K347KR, A376V, S379C, T386A |
| >4136-30321| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSITVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHREKIDELRQHLWSWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGPKALTEVVPLTKEAE LELAENREILREPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFRILKTGKYARMRGA HTNDVKQLTEAVQKIVTECIVIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |