Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4135 | 4135-30319 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, M184V, T215F | V75T, K219Q | K101E | A98G | K32Q, V35I, D123E, I135K, S162C, Q174R, G196E, T200TI, Q207E, R211K, V245Q, I257L, K277R, T286A, I293V, P294Q, E297K, D324E, I326T, Q334L, M357V, R358K, A360T, T377R, S379C |
| >4135-30319| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKRNPDIVI YQYVDDLYVGSDLEIEQHRIKIEELREHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDLQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVQLTKEAE LELAENREILKEPVHGVYYDPSKELTAEIQKQGLGQWTYQIYQEPFKNLKTGKYARVKGT HTNDVKQLTEAVQKIARECIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84V, L90M | V11I, Q58E, G73S, L89V | L10I, T12S, I13V, L19P, K20M, M36I, R41RK, I62V, L63P, A71V, I72IL |
| >4135-30319| codons 1-99 PQITLWQRPIISVKIGGQPMEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVREYD QVPIEICGHKVLSTVLVGPTPTNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |