<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4135 4135-30319 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82T, I84V, L90M V11I, Q58E, G73S, L89V L10I, T12S, I13V, L19P, K20M, M36I, R41RK, I62V, L63P, A71V, I72IL  
>4135-30319| codons 1-99
PQITLWQRPIISVKIGGQPMEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVREYD
QVPIEICGHKVLSTVLVGPTPTNVIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, L74I, M184V, T215F V75T, K219Q K101E A98G K32Q, V35I, D123E, I135K, S162C, Q174R, G196E, T200TI, Q207E, R211K, V245Q, I257L, K277R, T286A, I293V, P294Q, E297K, D324E, I326T, Q334L, M357V, R358K, A360T, T377R, S379C  
>4135-30319| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKRNPDIVI
YQYVDDLYVGSDLEIEQHRIKIEELREHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDLQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVQLTKEAE
LELAENREILKEPVHGVYYDPSKELTAEIQKQGLGQWTYQIYQEPFKNLKTGKYARVKGT
HTNDVKQLTEAVQKIARECIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006