<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4134 4134-30317 Germany 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82A, I84V L33F, K43T L10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93L  
>4134-30317| codons 1-99
PQITLWQRPIVTIKVEGQIVEALLDTGADDTVFENINLPGRWTPKMIVGIGGFVKVRQYD
QICIEICGKKAIGSVLVGPTPANVVGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K219R Y181C, G190A K101N, V108I P4S, V35T, T39E, E44D, V118I, K122E, D123S, K173A, T200A, E203K, Q207E, H208Y, R211K, D218E, H221Y, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, A376S, T377M, T386I, K390R  
>4134-30317| codons 1-399
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTILDVGDAYFSIPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDIVI
CQYMDDLYVASDLEIGQHRAKIKELREYLWKWGFYTPERKYQKEPPFHWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGAYYDPSKELIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKISMESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006