Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4134 | 4134-30317 | Germany | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, I84V | L33F, K43T | L10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93L |
| >4134-30317| codons 1-99 PQITLWQRPIVTIKVEGQIVEALLDTGADDTVFENINLPGRWTPKMIVGIGGFVKVRQYD QICIEICGKKAIGSVLVGPTPANVVGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | Y181C, G190A | K101N, V108I | P4S, V35T, T39E, E44D, V118I, K122E, D123S, K173A, T200A, E203K, Q207E, H208Y, R211K, D218E, H221Y, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, V317A, D324E, G335D, R356K, G359T, A376S, T377M, T386I, K390R |
| >4134-30317| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTILDVGDAYFSIPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDIVI CQYMDDLYVASDLEIGQHRAKIKELREYLWKWGFYTPERKYQKEPPFHWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGAYYDPSKELIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKISMESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |