<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4133 4133-30318 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M L10F, Q58E, G73T I13L, K20I, D60E, Q61HN, I62IV, L63P, I64V, K70KR, I85V  
>4133-30318| codons 1-99
PQITLWQRPFVTLKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFVKVREYE
NVPVEICGHRAITTVLVGPTPVNVVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184I, L210W, T215Y K219KR K101E, Y188L   E28K, V35L, T39A, K43E, E44D, A98S, V118I, K122E, I135V, I178M, V179I, V189I, G196E, E203D, H208Y, R211K, K223T, K275R, E297R, I329L, R356K, M357R, A360I, T377L  
>4133-30318| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALLEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII
YQYIDDLLIGSDLEIEQHRTKIDELRQYLWKWGFYTPDRKHQTEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVKQLCKLLRGTKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKRRGI
HTNDVKQLTEAVQKIALESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006