Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4133 | 4133-30318 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, Q58E, G73T | I13L, K20I, D60E, Q61HN, I62IV, L63P, I64V, K70KR, I85V |
| >4133-30318| codons 1-99 PQITLWQRPFVTLKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFVKVREYE NVPVEICGHRAITTVLVGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184I, L210W, T215Y | K219KR | K101E, Y188L | E28K, V35L, T39A, K43E, E44D, A98S, V118I, K122E, I135V, I178M, V179I, V189I, G196E, E203D, H208Y, R211K, K223T, K275R, E297R, I329L, R356K, M357R, A360I, T377L |
| >4133-30318| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALLEICAELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYIDDLLIGSDLEIEQHRTKIDELRQYLWKWGFYTPDRKHQTEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVKQLCKLLRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKRRGI HTNDVKQLTEAVQKIALESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |