Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4132 | 4132-30320 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K101E, Y181C | V108I | K20KR, V35M, T39A, K43E, R83K, V118I, K122E, K166R, I195IV, G196E, I202V, E203EK, R211K, E224D, A272P, K277R, T286A, A288S, I293V, E297KR, V317A, Q334L, G335S, M357T, G359S, A371V, T386P, A400L | E138AT |
| >4132-30320| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNTTPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI CQYVDDLYVGSDLEVEQHRTKVKELRQHLWKWGFYTPDKKHQKDPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTEVVPLTREAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGLSQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKPPKFKLPIQKETWEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, G73S | L10I, I13V, K14KR, L19I, K20R, L24F, E35D, M36I, N37D, I62V, L63P, A71V, I93L |
| >4132-30320| codons 1-99 PQITLWQRPIVTVRIGGQIREALFDTGADDTVFEDIDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |