Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4129 | 4129-30318 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 1 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y181V | K43E, E44A, V118I, K122KE, I142V, K166R, V179I, T200M, E203K, Q207D, H208Y, R211K, K223E, L228LH, A272P, K277R, K281R, I293IV, E297K, S322T, I326V, G333E, Q334N, G335C, M357V, G359S, V365I, A371V | N137H |
| >4129-30318| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINHETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIII VQYVDDLYVGSDLEIGQHRMKIKELRDYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPTKDLVAEIQKQENCQWTYQIYQEPFKNLKTGKYARVRSA HTNDIKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, F53FL, Q58E, T74P | L10I, V11L, I13V, K20R, E34Q, E35D, M36I, R41Q, K55KR, L63P, A71V, I72V, V77I, I93L |
| >4129-30318| codons 1-99 PQITLWQRPILTVKIGGQLREALLDTGADDTIFQDINLPGQWKPKIVGGIGGLLRVREYD QIPIEICGHKVVGPVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |