Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4129 | 4129-30314 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K219R | K103N | V108I, Y318F | K20R, T39A, E44D, V60I, V118I, D121Y, K122E, I142V, I195IT, T200E, E203K, Q207E, H208FY, R211K, H221Y, T286A, E297Q, R356RK, G359S, A371V, I375IV |
| >4129-30314| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL YEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLETGQHREKIKELREYLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTQEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKVATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L33F, F53FL, Q58E, G73GC, L89LV | L10IV, V11VL, I13V, G16GA, K20R, E35D, M36I, K55R, R57RK, L63P, K70E, A71V |
| >4129-30314| codons 1-99 PQITLWQRPVLTVKIAGQLREALLDTGADDTIFEDINLPGRWKPKIVGGIGGLMRVKEYD QIPIEICGHEVICTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |