Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4126 | 4126-30326 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LI, L210W, T215Y | K103N, Y181YC, Y188Y*FL | A98G, V108VI | S68G, D121H, K122E, S162SA, E203K, Q207E, R211K, K223KE, L228H, K277KR, E297A, E312EQ, I329L, Q334E, G359T, S379C |
| >4126-30326| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYMDDLLVGSDLEIGQHRTKIKELREHLWKWGFYTPDKKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVIPLTAEAE LELAENREILKQPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARMRTA HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | K20I, E35D, M36I, R57K, D60E, I62V, L63P, I64V, A71V, P79AS, I93L, T96TP |
| >4126-30326| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFLKVKQYE QVPVEICGHKVIGTVLVGSTPVNVIGRNLMTQLGCPLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |