Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4125 | 4125-30319 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A | L33F | L10I, I15IV, G16E, K20KR, M36MI, I62V, L63H, A71IV, T91TS, I93L |
| >4125-30319| codons 1-99 PQITLWQRPIVTIKVEGQLREALLDTGADDTVFEEINLPGRWKPKMIVGIGGFSKVRQYD QVHIEICGHKVIGTVLVGPTPANIIGRNLLSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67G, K219E | Y181I | K20R, K64H, T69N, V118I, K122E, I135T, Q174R, V179I, R211E, F214L, D218E, V245VI, A272P, V317A, Q334L, G359S, T369V, T386I |
| >4125-30319| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIHKKGSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIII IQYVDDLYVGSDLEIGQHRTKIEELRQHLLEWGLFTPEEKHQKEPPFLWMGYELHPDKWT VQPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLVEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |