<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4124 4124-30318 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, T215Y K219Q, N348I K103N, Y181V, Y188L   M16V, V35M, T39A, V118VI, K122KE, I135V, G196E, E203A, L210LS, D218E, L228H, A272P, K277R, T286A, E297AT, S322T, Q334P, G335NS, R356K, K366R, A376T, E399ED  
>4124-30318| codons 1-400
PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
VQYVDDLLVGSDLEIEQHRTKIAELRQHLSRWGFYTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTTEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGPSQWTYQIYQEPFKILKTGKYAKMRGA
HTNDVRQLTEAVQKITTESIVIWGKTPKFKLPIQKETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82S, L90LM L10F K20R, E35D, M36I, N37S, R41KT, K55KR, R57K, Q61QH, L63P, A71V, V77I, I93L  
>4124-30318| codons 1-99
PQITLWQRPFVTIKIGGQLREALLDTGADDTVLEDISLPGTWKPKIIGGIGGFVRVKQYD
HIPIEICGHKVIGTVLIGPTPSNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006