Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4124 | 4124-30318 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215Y | K219Q, N348I | K103N, Y181V, Y188L | M16V, V35M, T39A, V118VI, K122KE, I135V, G196E, E203A, L210LS, D218E, L228H, A272P, K277R, T286A, E297AT, S322T, Q334P, G335NS, R356K, K366R, A376T, E399ED |
| >4124-30318| codons 1-400 PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI VQYVDDLLVGSDLEIEQHRTKIAELRQHLSRWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTTEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGPSQWTYQIYQEPFKILKTGKYAKMRGA HTNDVRQLTEAVQKITTESIVIWGKTPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S, L90LM | L10F | K20R, E35D, M36I, N37S, R41KT, K55KR, R57K, Q61QH, L63P, A71V, V77I, I93L |
| >4124-30318| codons 1-99 PQITLWQRPFVTIKIGGQLREALLDTGADDTVLEDISLPGTWKPKIIGGIGGFVRVKQYD HIPIEICGHKVIGTVLIGPTPSNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |