Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4120 | 4120-30403 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, K43T, F53L, T74P | L10I, I13V, L24F, I62V, L63P, A71V, V77I, I93L |
| >4120-30403| codons 1-99 PQITLWQRPIVTVKIGGQLKEALFDTGADDTVFEEMNLPGRWTPKLIGGIGGLVKVRQYD QVPIEICGHKVIGPVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, L210W, T215Y | K219E | L100I, K103N | E40X, E44ED, V118I, D123E, D177N, T200A, Q207E, H208Y, R211K, D218E, L228H, Q242H, A272P, K311R, I329V, Q334L, G335S, G359S, A371V, E399D, A400S |
| >4120-30403| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTXLEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYVDDLYVGSDLEIGQHRAKIEELREYLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEVQKQGLSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWDS |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |