Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4119 | 4119-30403 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V, L90M | L10F, L33F, K43KT, G73T | I13V, G16A, R41K, K55R, R57K, I62V, L63P, I66F, A71T, I72T |
| >4119-30403| codons 1-99 PQITLWQRPFVTVKIAGQLKEALLDTGADDTVFEEMNLPGKWTPKIIGGIGGFVRVKQYD QVPIEFCGHKTTTTVLVGPTPTNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | V35M, T39TK, K43E, E44D, R83K, I94IL, K101Q, V118I, K122E, I135T, R211RK, D218E, I244V, A272P, V276T, K277R, L283I, A288T, I293V, S322A, Q334H, R356K, G359C, T369A, A371V, K374R, I375V, A376T, S379C, T386TA, K388R, K390KR |
| >4119-30403| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICKELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKKTQDFWEVQLGLPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLIRGTKTLTEVVPLTEEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYAKMRCA HTNDVKQLAEVVQRVTTECIVIWGKAPRFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |