<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4119 4119-30403 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V, L90M L10F, L33F, K43KT, G73T I13V, G16A, R41K, K55R, R57K, I62V, L63P, I66F, A71T, I72T  
>4119-30403| codons 1-99
PQITLWQRPFVTVKIAGQLKEALLDTGADDTVFEEMNLPGKWTPKIIGGIGGFVRVKQYD
QVPIEFCGHKTTTTVLVGPTPTNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y       V35M, T39TK, K43E, E44D, R83K, I94IL, K101Q, V118I, K122E, I135T, R211RK, D218E, I244V, A272P, V276T, K277R, L283I, A288T, I293V, S322A, Q334H, R356K, G359C, T369A, A371V, K374R, I375V, A376T, S379C, T386TA, K388R, K390KR  
>4119-30403| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICKELEEDGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKKTQDFWEVQLGLPHPAGLQKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT
VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLIRGTKTLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPAKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYAKMRCA
HTNDVKQLAEVVQRVTTECIVIWGKAPRFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006