Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4118 | 4118-30407 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I54V, I84V, L90M | L10F, V11VI, L33F, G73GS, T74TP | T4A, I13V, K20R, E35D, M36I, N37S, R41K, R57RK, I62IV, L63P, K70E, A71V, I72IV, P79PA, I93L |
| >4118-30407| codons 1-99 PQIALWQRPFITVKIGGQLREALLDTGADDTVFEDISLPGKWKPKLIGGIGGFVKVKQYD QVPIEICGHEVVSPVLVGATPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | A62V, K70N, V75I, F77L, F116Y | K103N | V108I, P225H | K43E, T58N, K122KE, D123DE, I135T, S163A, I178M, T200A, R211K, F214M, L228H, I326V, Q334L, V365I, T386IV, K390R, E399G, A400S |
| >4118-30407| codons 1-401 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEEEGKISKIGPENPYNNPV FVIKKKDSTNWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAFYSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSAMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLKWGMTTPDKKHQKEHPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGA HTNDIKQLTEAVQKIATESIVIWGKVPKFRLPIQKETWGSW |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |