Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4116 | 4116-30324 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | Q58E, G73S | L10I, T12S, I13IV, L19I, K20I, M36I, N37S, Q61E, I62V, L63P, H69K, A71V, I72T, Q92K |
| >4116-30324| codons 1-99 PQITLWQRPIVSVKIGGQIIEALLDTGADDTVLEEISLPGRWKPKIIGGIGGFVKVREYD EVPIEICGKKVTSTVLVGPTPANIIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | K219N | L100I, K103N | I5V, V118I, K122E, D123E, H208Y, R211K, D218E, T286A, P294T, E297K, I329V, Q334E, P345I, F346H, R356K, M357MR, A371V, A376S |
| >4116-30324| codons 1-399 PISPVETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVITLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGEGQWTYQIYQEIHKNLKTGKYAKRRGA HTNDVKQLTEVVQKISTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |