Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4114 | 4114-30403 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75M, M184V, L210W, T215Y | F77L, K219N, N348I | K103N | K43E, E44A, V118I, K122E, D123E, T200A, H208Y, R211K, D218E, L228H, A272P, K277R, L283I, I293V, Q334E, I341F, R356K, M357K, A371V, I375M |
| >4114-30403| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKIMDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPENKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQFYQEPFKILKTGKYAKKRGA HTNDVKQLTEVVQKMATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, I47V, I54L, V82A, I84V, L90M | L33F, Q58E, L89V | L10I, I13V, Q18QH, K20R, E34EQ, E35D, M36I, N37D, K55R, I62V, L63P, A71V | T74TI |
| >4114-30403| codons 1-99 PQITLWQRPIVTVKIGGHLREALLDTGADDTIFQDIDLPGRWKPKIVGGIGGFLRVREYD QVPIEICGHKVIGIVLVGPTPANVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |