<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4114 4114-30403 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, V75M, M184V, L210W, T215Y F77L, K219N, N348I K103N   K43E, E44A, V118I, K122E, D123E, T200A, H208Y, R211K, D218E, L228H, A272P, K277R, L283I, I293V, Q334E, I341F, R356K, M357K, A371V, I375M  
>4114-30403| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKIMDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPENKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQFYQEPFKILKTGKYAKKRGA
HTNDVKQLTEVVQKMATESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46MI, I47V, I54L, V82A, I84V, L90M L33F, Q58E, L89V L10I, I13V, Q18QH, K20R, E34EQ, E35D, M36I, N37D, K55R, I62V, L63P, A71V T74TI
>4114-30403| codons 1-99
PQITLWQRPIVTVKIGGHLREALLDTGADDTIFQDIDLPGRWKPKIVGGIGGFLRVREYD
QVPIEICGHKVIGIVLVGPTPANVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006