<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4113 4113-30319 Germany 2003 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F K219E Y181C, G190A V108I E6D, K11T, V35T, T39K, K43E, V60I, T69N, L109I, K122E, D123S, S162SC, K173I, Q174K, D177E, T200K, Q207A, R211S, D218E, L228H, Q242H, V245E, K249R, T286A, E291D, V292I, I293V, P294PT, E297A, E312NS, D324DE, I326V, I329V, G335D, M357K, G359S, K366R, A371V, T377TI, K390R, E399D  
>4113-30319| codons 1-399
PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPI
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTIIDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRIKNPEIVI
CQYVDDLYVASDLEIGQHRKKIEELRAHLLSWGFFTPEEKHQKEPPFHWMGYELHPDKWT
VHPIELPERDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTAEAE
LELAENREILKSPVHGVYYDPSKELVAEVQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVRQLTEVVQKIAIESIVIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A   L10I, I13V, G16E, L19I, K20I, E35D, M36I, P39S, R41K, D60DE, I62V, H69K, K70R, A71IV, I72V, T74A, L89I  
>4113-30319| codons 1-99
PQITLWQRPIVTVKIEGQIIEALLDTGADDTVLEDINLSGKWKPKMIGGIGGFVKVRQYE
QVLIEICGKRVVGAVLVGPTPANIIGRNILTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006