Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4113 | 4113-30319 | Germany | 2003 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219E | Y181C, G190A | V108I | E6D, K11T, V35T, T39K, K43E, V60I, T69N, L109I, K122E, D123S, S162SC, K173I, Q174K, D177E, T200K, Q207A, R211S, D218E, L228H, Q242H, V245E, K249R, T286A, E291D, V292I, I293V, P294PT, E297A, E312NS, D324DE, I326V, I329V, G335D, M357K, G359S, K366R, A371V, T377TI, K390R, E399D |
| >4113-30319| codons 1-399 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPI FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTIIDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRIKNPEIVI CQYVDDLYVASDLEIGQHRKKIEELRAHLLSWGFFTPEEKHQKEPPFHWMGYELHPDKWT VHPIELPERDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTAEAE LELAENREILKSPVHGVYYDPSKELVAEVQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA HTNDVRQLTEVVQKIAIESIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10I, I13V, G16E, L19I, K20I, E35D, M36I, P39S, R41K, D60DE, I62V, H69K, K70R, A71IV, I72V, T74A, L89I |
| >4113-30319| codons 1-99 PQITLWQRPIVTVKIEGQIIEALLDTGADDTVLEDINLSGKWKPKMIGGIGGFVKVRQYE QVLIEICGKRVVGAVLVGPTPANIIGRNILTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |