<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4108 4108-30304 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75M, M184V, L210W   K101E, G190S   K20R, V35I, K43Q, E44D, V60I, V106I, V118I, K122E, D123N, K166R, Q207E, H208Y, R211K, A272P, I293V, V317A, G333E, Q334N, G335S, F346Y, K350R, G359S, T369V, T386V, K390R, E399D  
>4108-30304| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYVDDLYVSSDLEIGQHRTKIEELREYLWKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQENSQWTYQIYQEPYKNLRTGKYARMRSA
HTNDVKQLVEAVQKIATESIVIWGKVPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, L90M L33F, F53L, N83D L10I, T12P, I15IV, E34Q, R41K, I62V, L63P, C67W, A71I, I72V, G73D, V77I, V82I, Q92K, I93L  
>4108-30304| codons 1-99
PQITLWQRPIVPIKVGGQLKEALLDTGADDTIFQEMNLPGKWKPKIVGGIGGLMKVRQYD
QVPIEIWGHKIVDTVLIGPTPIDIIGRNLMTKLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006