Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4108 | 4108-30304 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L33F, F53L, N83D | L10I, T12P, I15IV, E34Q, R41K, I62V, L63P, C67W, A71I, I72V, G73D, V77I, V82I, Q92K, I93L |
| >4108-30304| codons 1-99 PQITLWQRPIVPIKVGGQLKEALLDTGADDTIFQEMNLPGKWKPKIVGGIGGLMKVRQYD QVPIEIWGHKIVDTVLIGPTPIDIIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W | K101E, G190S | K20R, V35I, K43Q, E44D, V60I, V106I, V118I, K122E, D123N, K166R, Q207E, H208Y, R211K, A272P, I293V, V317A, G333E, Q334N, G335S, F346Y, K350R, G359S, T369V, T386V, K390R, E399D |
| >4108-30304| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRTKIEELREYLWKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQENSQWTYQIYQEPYKNLRTGKYARMRSA HTNDVKQLVEAVQKIATESIVIWGKVPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |