Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4107 | 4107-30304 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_ES, K70R, L210W, T215SY | D67S, N348I | Y181C, Y188L, G190GA | E6K, K20R, T39TA, V106I, K122E, I142IT, S162A, R172RK, I178IL, T200I, R211K, D218DE, A272P, T286A, E297R, Q334E, R356K, M357T, A376S, K390R, E399D |
| >4107-30304| codons 1-399 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV FAIKKKSSSRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQASMTKILEPFKKQNPDLVI CQYMDDLLVASDLEIGQHRIKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKILKTGKYAKTRGA HTNDVKQLTEAVQKISTESIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | K43T, G73S, L89V | L10I, I15V, K20R, E35D, M36I, N37D, K55R, R57K, D60E, I62V, L63P, H69R, A71I, I85V, I93L |
| >4107-30304| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWTPKIIGGVGGFVRVKQYE QVPIEICGRKIISTVLVGPTPANIVGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |