<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4107 4107-30304 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A, L90M K43T, G73S, L89V L10I, I15V, K20R, E35D, M36I, N37D, K55R, R57K, D60E, I62V, L63P, H69R, A71I, I85V, I93L  
>4107-30304| codons 1-99
PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWTPKIIGGVGGFVRVKQYE
QVPIEICGRKIISTVLVGPTPANIVGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T69S_ES, K70R, L210W, T215SY D67S, N348I Y181C, Y188L, G190GA   E6K, K20R, T39TA, V106I, K122E, I142IT, S162A, R172RK, I178IL, T200I, R211K, D218DE, A272P, T286A, E297R, Q334E, R356K, M357T, A376S, K390R, E399D  
>4107-30304| codons 1-399
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV
FAIKKKSSSRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQASMTKILEPFKKQNPDLVI
CQYMDDLLVASDLEIGQHRIKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKILKTGKYAKTRGA
HTNDVKQLTEAVQKISTESIVIWGKTPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006