Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4106 | 4106-30225 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | N348I | K103N | K238T | K43E, V60I, R83K, V118VI, I142IV, R211K, D218DE, L228LH, V245E, E248D, T286A, I293V, T296TS, E297K, D324E, M357K, T377R |
| >4106-30225| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPEKKHQKEPPFHWMGYELHPDTWT VQPIELPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLSKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKILKTGKYARKRGA HTNDVKQLTEAVQKIARESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | L10F, L33F, K43T, G73S | I13IV, I62V, L63P, C67F, H69K, A71V, I72T |
| >4106-30225| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWTPKIIGGIGGFVKVRQYD QVPIEIFGKKVTSTVLVGPTPANVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |