Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4105 | 4105-30225 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A | L10F | L63P, A71V, I93L |
| >4105-30225| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTILEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, M184V, L210W, T215Y | K103N | K43N, V60I, S68SG, V118I, K122E, D123DN, I135T, T139M, T165I, R211K, K223KQ, T286A, A288S, E297K, I326V, G359S, V365I, A371V, K390R |
| >4105-30225| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPI FAIKKKNGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNEMPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDIKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |