<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4104 4104-30224 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84V, L90M L33F, F53FL, Q58E T4S, L10I, V11L, I13V, G16E, L19I, M36I, Q61R, L63T, L89I, T91S  
>4104-30224| codons 1-99
PQISLWQRPILTVKIEGQIKEALLDTGADDTVFEEINLPGRWKPKIIGGIGGLVKVREYD
RITIEICGHKAIGTVLVGPTPANVIGRNIMSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75L K103N, G190GA V108VI V35L, T39A, K43E, V118I, K122KE, I135T, S162D, E169D, D177E, I178IM, V189VI, H208Y, R211K, V245E, A272P, V276T, Q334N, G335S, M357T, R358K, I375IV, V381VI, K390R, E399EG  
>4104-30224| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILDPFRKQNPEMVI
YQYVDDLYIASDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKTKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVKQLTEAVQKVATESIIIWGKTPKFRLPIQKETWGA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006