Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4104 | 4104-30224 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | L33F, F53FL, Q58E | T4S, L10I, V11L, I13V, G16E, L19I, M36I, Q61R, L63T, L89I, T91S |
| >4104-30224| codons 1-99 PQISLWQRPILTVKIEGQIKEALLDTGADDTVFEEINLPGRWKPKIIGGIGGLVKVREYD RITIEICGHKAIGTVLVGPTPANVIGRNIMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V75L | K103N, G190GA | V108VI | V35L, T39A, K43E, V118I, K122KE, I135T, S162D, E169D, D177E, I178IM, V189VI, H208Y, R211K, V245E, A272P, V276T, Q334N, G335S, M357T, R358K, I375IV, V381VI, K390R, E399EG |
| >4104-30224| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILDPFRKQNPEMVI YQYVDDLYIASDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKTKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKVATESIIIWGKTPKFRLPIQKETWGA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |