<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4103 4103-30224 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219N Y181C, Y188L   K20KR, E28K, K32E, V35I, T39A, E44D, I94L, V118I, K122E, I135T, Q174QR, V179I, G196E, I202IV, E203K, Q207E, H208Y, R211K, K223E, D237E, I244IV, T286A, E291ED, I293IV, E297K, L301M, G359S, A371AT, T386IV  
>4103-30224| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALIEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGLPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIII
CQYMDDLLVGSDLEIEQHRTKVKELREYLWKWGFYTPDNKHQEEPPFLWMGYELHPEKWT
VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVPLTKEAE
MELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTETVQKIATESIVIWGKVPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47IV, I54V, V82F, L90M Q58E, G73C L10I, T12Q, I13M, K14R, K20I, E35ED, M36I, R41K, D60E, Q61N, I62V, L63P, I64V, I66IV, K70R, I72V, V77I  
>4103-30224| codons 1-99
PQITLWQRPIVQMRIGGQLIEALLDTGADDTVLEDINLPGKWKPKIVGGIGGFVKVREYE
NVPVEVCGHRAVCTVLIGPTPFNIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006