Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4103 | 4103-30224 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54V, V82F, L90M | Q58E, G73C | L10I, T12Q, I13M, K14R, K20I, E35ED, M36I, R41K, D60E, Q61N, I62V, L63P, I64V, I66IV, K70R, I72V, V77I |
| >4103-30224| codons 1-99 PQITLWQRPIVQMRIGGQLIEALLDTGADDTVLEDINLPGKWKPKIVGGIGGFVKVREYE NVPVEVCGHRAVCTVLIGPTPFNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | Y181C, Y188L | K20KR, E28K, K32E, V35I, T39A, E44D, I94L, V118I, K122E, I135T, Q174QR, V179I, G196E, I202IV, E203K, Q207E, H208Y, R211K, K223E, D237E, I244IV, T286A, E291ED, I293IV, E297K, L301M, G359S, A371AT, T386IV |
| >4103-30224| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGLPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIII CQYMDDLLVGSDLEIEQHRTKVKELREYLWKWGFYTPDNKHQEEPPFLWMGYELHPEKWT VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVPLTKEAE MELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTETVQKIATESIVIWGKVPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |