Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4100 | 4100-30224 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215F | K219Q | K103S, G190A | V35LM, K43KN, T69N, D123E, S162CW, V179I, T200AV, Q207E, D218E, L228H, A272P, R284K, T286A, E297K, K347Q, K350KR, M357MI, G359S, K366R, A376AT, S379C |
| >4100-30224| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELENEGKISKIGPENPYNTPV FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII YQYMDDLYVASDLEIGQHRVKIEELREHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFQNLRTGKYARIRSA HTNDVRQLTEAVQKITTECIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10F, Q58E, G73S | T4P, K20R, E35D, M36I, K55R, I62V, L63P, A71V, I72V, I93L, C95F |
| >4100-30224| codons 1-99 PQIPLWQRPFVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVRVREYD QVPIEICGHKVVSTVLVGPTPANIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |