<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4100 4100-30224 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L10F, Q58E, G73S T4P, K20R, E35D, M36I, K55R, I62V, L63P, A71V, I72V, I93L, C95F  
>4100-30224| codons 1-99
PQIPLWQRPFVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVRVREYD
QVPIEICGHKVVSTVLVGPTPANIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, T215F K219Q K103S, G190A   V35LM, K43KN, T69N, D123E, S162CW, V179I, T200AV, Q207E, D218E, L228H, A272P, R284K, T286A, E297K, K347Q, K350KR, M357MI, G359S, K366R, A376AT, S379C  
>4100-30224| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELENEGKISKIGPENPYNTPV
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPDIII
YQYMDDLYVASDLEIGQHRVKIEELREHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFQNLRTGKYARIRSA
HTNDVRQLTEAVQKITTECIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006