<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4099 4099-30218 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y   Y188L, P236PL Y318YF T39A, K43E, V118I, D121H, K122E, S163C, D177E, V179I, V189VI, E203K, Q207E, H208Y, R211K, K223E, A272P, T286A, E297K, S322T, Q334E, P345Q, M357T, A360T  
>4099-30218| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSCMTKILEPFRKQNPEIII
YQYVDDLLIGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQEEPPFLWMGYELHLDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVFYDPTKDLIAEIQKQGEGQWTYQIYQEQFKNLKTGKYARTRGT
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V, L90M L33F, Q58E, G73A L10I, I13V, K20R, E35D, M36I, K55R, I62V, L63P, I66IF, A71V, I72L, Q92QR  
>4099-30218| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDINLPGRWKPKLIGGIGGFVRVREYD
QVPIEFCGHKVLATVLVGPTPANVIGRNLMTRIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006