Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4099 | 4099-30218 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L33F, Q58E, G73A | L10I, I13V, K20R, E35D, M36I, K55R, I62V, L63P, I66IF, A71V, I72L, Q92QR |
| >4099-30218| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDINLPGRWKPKLIGGIGGFVRVREYD QVPIEFCGHKVLATVLVGPTPANVIGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | Y188L, P236PL | Y318YF | T39A, K43E, V118I, D121H, K122E, S163C, D177E, V179I, V189VI, E203K, Q207E, H208Y, R211K, K223E, A272P, T286A, E297K, S322T, Q334E, P345Q, M357T, A360T |
| >4099-30218| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSCMTKILEPFRKQNPEIII YQYVDDLLIGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQEEPPFLWMGYELHLDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVFYDPTKDLIAEIQKQGEGQWTYQIYQEQFKNLKTGKYARTRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |