Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4097 | 4097-30509 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219R, N348I | Y188L | K43E, E44A, K49R, V60I, V90I, V106I, V118I, I135T, S163A, K166T, V179VI, I202V, H208Y, R211K, K223T, A272P, K277R, T286A, Q334E, K347KE, M357MT, R358RK, K388KR, K390R | P294PKQT |
| >4097-30509| codons 1-398 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISRIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSAMTTILEPFRKQNPDIII YQYVDDLLVGSDLEIGQHRTKVEELRQYLWKWGFYTPDRKHQTEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVITLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFEILKTGKYARTKGA HTNDVKQLTEAVQKIATESIVIWGKTPRFRLPIQKETW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, I84V, L90M | L10F, L33LF, K43KT, Q58QE, G73GS, L89V | I13IV, L19I, K20R, E35D, M36I, N37ND, D60E, L63P, A71V |
| >4097-30509| codons 1-99 PQITLWQRPFVTVKIGGQIREALLDTGADDTIFEDIDLPGRWTPKMVGGIGGFMKVREYE QIPIEICGHKVISTVLVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |