Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4093 | 4093-30324 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215Y | K219E | K103N | V108I | V35IT, K102N, D121H, K122E, I135L, A158S, S162C, D177E, I178M, V179I, V189VI, L228H, V245E, Q278E, T286A, I293V, E297A, Q334L, F346Y, M357T, G359S, A371V, T386TI |
| >4093-30324| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKNNKSVTILDVGDAYFSVPL HEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPSIFQCSMTKILEPFRKQNPEMII YQYVDDLYIGSDLEIGQHRTKIEELRQHLLRWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKELCKLLRGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPYKNLKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, I84V, L90M | L10F | Q7R, K20I, M36I, R41K, L63P, H69R, A71V, I72V, I93L |
| >4093-30324| codons 1-99 PQITLWRRPFVTIKIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIVGIGGFVKVRQYD QIPIEICGRKVVGTVLVGPTPANVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |