<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4093 4093-30324 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82A, I84V, L90M L10F Q7R, K20I, M36I, R41K, L63P, H69R, A71V, I72V, I93L  
>4093-30324| codons 1-99
PQITLWRRPFVTIKIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIVGIGGFVKVRQYD
QIPIEICGRKVVGTVLVGPTPANVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V, T215Y K219E K103N V108I V35IT, K102N, D121H, K122E, I135L, A158S, S162C, D177E, I178M, V179I, V189VI, L228H, V245E, Q278E, T286A, I293V, E297A, Q334L, F346Y, M357T, G359S, A371V, T386TI  
>4093-30324| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKNNKSVTILDVGDAYFSVPL
HEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPSIFQCSMTKILEPFRKQNPEMII
YQYVDDLYIGSDLEIGQHRTKIEELRQHLLRWGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKELCKLLRGAKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPYKNLKTGKYARTRSA
HTNDVKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006