Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4090 | 4090-30326 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A, L90M | L33F, G73S, L89V | L10I, I13V, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, A71V, I72M |
| >4090-30326| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGKWKPKLIGGIGGFVRVKQYD QVPIEICGHKVMSTVVVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, M184V, T215F | K219Q | Y188L | A98G | T39A, V60I, V106I, V118I, K122E, I135T, S162SN, K173T, Q174K, N175Y, V179VI, T200E, R211T, F214L, D218E, E224ED, L228H, V245K, R284K, T286A, A288AT, I293V, Q334L, K350R, G359S, T386I |
| >4090-30326| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPIF AIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSITVLDVGDAYFSIPLD EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRTKYPDIIIY QYVDDLLVGSDLEIGQHREKIEELRQHLLTWGLFTPEQKHQKDPPFHWMGYELHPDKWTV QPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKTLTEVVPLTEEAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLRTGKYARMRSAH TNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |