<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4090 4090-30326 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, V82A, L90M L33F, G73S, L89V L10I, I13V, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, A71V, I72M  
>4090-30326| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGKWKPKLIGGIGGFVRVKQYD
QVPIEICGHKVMSTVVVGPTPANIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74I, M184V, T215F K219Q Y188L A98G T39A, V60I, V106I, V118I, K122E, I135T, S162SN, K173T, Q174K, N175Y, V179VI, T200E, R211T, F214L, D218E, E224ED, L228H, V245K, R284K, T286A, A288AT, I293V, Q334L, K350R, G359S, T386I  
>4090-30326| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPIF
AIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSITVLDVGDAYFSIPLD
EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRTKYPDIIIY
QYVDDLLVGSDLEIGQHREKIEELRQHLLTWGLFTPEQKHQKDPPFHWMGYELHPDKWTV
QPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKTLTEVVPLTEEAEL
ELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLRTGKYARMRSAH
TNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006