Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4089 | 4089-30306 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | N348I | K103N | V35VI, K43KN, E44D, V111I, V118I, K122E, I135IL, S162C, I178L, T200A, R211A, A272P, K277R, I326V, Q334L, M357T, R358K, V365I, E399G |
| >4089-30306| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWAWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKILKTGKYARTKGA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWGA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I54L, I84V, L90M | V11I, L33F, K43T, G73S, T74P, L89V | L5F, L10I, I13V, E34Q, L63P, A71V, V77I, I93L |
| >4089-30306| codons 1-99 PQITFWQRPIITVKIGGQLKEALLDTGADDTIFQEMNLPGRWTPKLIGGIGGFLKVRQYD QIPIEICGHKVISPVLIGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |