<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4089 4089-30306 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46L, I54L, I84V, L90M V11I, L33F, K43T, G73S, T74P, L89V L5F, L10I, I13V, E34Q, L63P, A71V, V77I, I93L  
>4089-30306| codons 1-99
PQITFWQRPIITVKIGGQLKEALLDTGADDTIFQEMNLPGRWTPKLIGGIGGFLKVRQYD
QIPIEICGHKVISPVLIGPTPVNVIGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, L210W, T215Y N348I K103N   V35VI, K43KN, E44D, V111I, V118I, K122E, I135IL, S162C, I178L, T200A, R211A, A272P, K277R, I326V, Q334L, M357T, R358K, V365I, E399G  
>4089-30306| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAYFSIPL
DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRAKIEELRQHLWAWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKILKTGKYARTKGA
HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWGA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006