<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4085 4085-30702 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I50V, L90M L10F, L33F I13IV, N37S, L63LP, I64IV, I66F, A71V  
>4085-30702| codons 1-99
PQITLWQRPFVTVKIGGQLKEALLDTGADDTIFEEMSLPGRWKPKIIGGVGGFIKVRQYD
QIPVEFCGHKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74I, M184V, T215Y N348NI     E6D, S68SG, K102KQ, K122E, I142T, E169D, I202V, K277R, Q278E, P294T, E297R, K311R, I329IL, G333E, G335C, M357V, K366R, A376T, T386I K166KPQT
>4085-30702| codons 1-399
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTTILDPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGTKALTEVITLTREAE
LELAENREILREPVHGVYYDPSKDLIAELQKQEQCQWTYQIYQEPFKILKTGKYARVRGA
HTNDVRQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006