Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4085 | 4085-30702 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I50V, L90M | L10F, L33F | I13IV, N37S, L63LP, I64IV, I66F, A71V |
| >4085-30702| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADDTIFEEMSLPGRWKPKIIGGVGGFIKVRQYD QIPVEFCGHKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74I, M184V, T215Y | N348NI | E6D, S68SG, K102KQ, K122E, I142T, E169D, I202V, K277R, Q278E, P294T, E297R, K311R, I329IL, G333E, G335C, M357V, K366R, A376T, T386I | K166KPQT |
| >4085-30702| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTTILDPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGTKALTEVITLTREAE LELAENREILREPVHGVYYDPSKDLIAELQKQEQCQWTYQIYQEPFKILKTGKYARVRGA HTNDVRQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |