Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4084 | 4084-30522 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | K20R, M36I, K55R, I62V, L63P, A71V |
| >4084-30522| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTILEEINLPGRWKPKIIGGIGGFVRVRQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69DE, K70R, M184V | T215V, K219Q | K101KPQT, K103N, Y188YFHL | E6EK, K20KR, V35M, A98AS, K102KE, V118I, K122E, D123N, I135T, S162CY, V179VI, G196E, F214L, L228H, E291D, E297KR, K311R, R356RK, M357MI, A360V, K390R, E399D | K104KHNQ |
| >4084-30522| codons 1-399 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPSGLTENQSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII YQYVDDLLVGSDLEIEQHRTKIEELRQHLLRWGLVTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVIPLTREAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKIRGV HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |