<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2084 CA7713 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 261
2 AZT+ 3TC 41
3 D4T+ 3TC+ IDV 48
4 DDC+ 3TC+ NFV 28
5 DDI+ 3TC+ NFV 22

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, N88S L10F, Q58QE I13V, K14R, K20I, N37D, L63Q, I64V, I72V, I93L  
>CA7713| codons 7-99
QRPFVTVRIGGQLIEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVREYDQIQVEI
CGHKAVGTVLVGPTPVNIIGRSLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, M184V K70T, K219Q     K20R, T39N, V60I, T69N, D123E, I135T, D177E, D218E, A272P  
>CA7712| codons 1-283
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNEMEKEGKISKIGPENPYNTPI
FAIKKKNSNTWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLL

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005