Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4082 | 4082-30306 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215F | K219Q | K103S, G190A | V60I, K101Q, K122E, I135T, V179VI, D192DN, Q197E, Q207E, L228H, Q242L, K277R, T286A, A288S, E297K, Q334L, A360V, A376T, T386A, K390KR |
| >4082-30306| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLQKSKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVASNLEIGEHRTKIEELREHLWRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VLPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGV HTNDVKQLTEAVQKITTESIVIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73S | T4S, E35D, I62V, L63P, A71I, I72R, P79N, I93L |
| >4082-30306| codons 1-99 PQISLWQRPFVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKIRSTVLVGNTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |