Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4081 | 4081-30228 | Germany | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V | L10V, I13A, K14R, K20I, A22V, E35D, M36I, N37S, R41K, Q61H, I66F, H69K, K70R, P79S, L89I, T91TS |
| >4081-30228| codons 1-99 PQITLWQRPVVTARIGGQLIEVLLDTGADDTVLEDISLPGKWKPKLIGGIGGFVKVRQYD HILIEFCGKRAIGTVLVGSTPVNVIGRNILSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215Y | K219Q | V35T, T39L, D123E, I135V, A158AS, S162A, K173T, Q174A, D177E, T200A, Q207E, D218E, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, T369V, A371V, I375V, A376S, K390R, K395R |
| >4081-30228| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICLEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPSIFQASMTKILEPFRTANPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPTKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLVEVVQKVSTESIVIWGKTPKFRLPIQRETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |